Abstract: This review addresses the literature surrounding Parkinson’s disease (PD) and mild cognitive impairment (MCI).
It discusses the neuropsychological, pharmaceutical, and pathological overlap, the socioeconomic impact of PD and MCI, and the value of recognizing,understanding, and treating MCI in PD.
It is concluded from this review that MCI in PD does exist and should be considered in clinical and research investigations. Due to the lack of accepted clinical criteria, an inclusive operating definition of MCI in PD is proposed.
Research guidelines for studying the presence of MCI in PD and evaluating the efficacy of pharmaceutical interventions are also suggested.
Abstract: This review addresses the literature surrounding Parkinson’s disease (PD) and mild cognitive impairment (MCI). It discusses the neuropsychological, pharmaceutical, and pathological overlap, the socioeconomic impact of PD and MCI, and the value of recognizing,understanding, and treating MCI in PD. It is concluded from this review that MCI in PD does exist and should be considered in clinical and research investigations. Due to the lack of accepted clinical criteria, an inclusive operating definition of MCI in PD is proposed. Research guidelines for studying the presence of MCI in PD and evaluating the efficacy of pharmaceutical interventions are also suggested.
Authors:
Hubert H Fernandez1
Gregory P Crucian1
Michael S Okun1
Catherine C Price2
Dawn Bowers2
1Department of Neurology,
2Department of Clinical and Health
Psychology, University of Florida,
Gainesville, FL, USA
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